Understanding Cialis and its Mechanism of Action

Cialis works by increasing blood flow to the penis. This happens because it inhibits a specific enzyme, phosphodiesterase-5 (PDE5). PDE5 normally breaks down a chemical called cyclic guanosine monophosphate (cGMP), which is crucial for causing penile erection. By blocking PDE5, Cialis allows cGMP to persist, leading to vasodilation and increased blood flow.

Factors Affecting Cialis’s Effectiveness

Several factors influence Cialis’s effectiveness. Liver and kidney function play significant roles in how the body processes the drug. Certain medications, including nitrates, interact negatively with Cialis and should be avoided. Pre-existing health conditions like heart disease may also influence its efficacy. Always consult your doctor before starting Cialis, especially if you have underlying health issues or take other medications.

Diet and lifestyle choices also affect its effectiveness. Maintaining a healthy weight, engaging in regular physical activity, and following a balanced diet contribute to overall health and can positively influence the body’s response to medication. Alcohol consumption can affect the efficacy, and smoking negatively impacts circulation.